Cyclobenzaprine: MedlinePlus Drug Information

Cyclobenzaprine: MedlinePlus Drug Information

The patient should rinse their mouth to ensure that they have swallowed all the contents. Cyclobenzaprine caused slight to moderate increase in heart rate in animals. Cyclobenzaprine reduced or abolished skeletal muscle hyperactivity in several animal models. Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle. Such studies show that cyclobenzaprine acts primarily within the central nervous system at brain stem as opposed to spinal cord levels, although its action on the latter may contribute to its overall skeletal muscle relaxant activity. Evidence suggests that the net effect of cyclobenzaprine is a reduction of tonic somatic motor activity, influencing both gamma (γ) and alpha (α) motor systems.

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For non-prescription products, read the label or package ingredients carefully. People might also use Flexeril as a way to come down from Stimulant drugs, such as Cocaine or Adderall. When people addicted to Flexeril attempt to stop taking it or reduce their doses they may start to experience withdrawal symptoms, although these are typically not severe.

If you experience any of the following symptoms, call your doctor immediately:

It works by blocking pain sensations that are sent to your brain. A long-acting formulation of cyclobenzaprine has been introduced and is believed by some clinicians to have a lower side effect profile than the immediate-release formulation of this drug. Laguna Treatment Hospital—our rehab facility in Orange County, CA—utilizes effective, evidence-based approaches through a variety of levels of addiction treatment that can help you or your loved one get sober and remain in recovery. While the addictiveness of cyclobenzaprine is being debated, anyone exhibiting problematic patterns of substance use can benefit from addiction treatment. This is especially true if someone has been engaging in polydrug use with cyclobenzaprine and other substances. However, the half-life of immediate-release cyclobenzaprine is 18 hours on average, with a range of 8-37 hours.

You also get to gain insight into what caused it to occur for you in the first place. Maybe you were depressed or anxious and Flexeril offered you a way to feel calm. No matter what the reason is, understanding it is critical because then, the cause can be treated. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.

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This can help keep levels of this drug from building up too much in your body. According to the National Institute on Drug Abuse or NIDA, more than 50 million Americans aged 12 and over have reportedly misused a prescription drug at least once in their life. There were 25.2 million prescriptions wrote in 2011 that included cyclobenzaprine such as Flexeril. It’s not considered a dangerous method of getting rid of specific muscular pain.

Patient Handout

All patients suspected of an overdose with FLEXERIL should receive gastrointestinal decontamination. This should include large volume gastric lavage followed by activated charcoal. If consciousness is impaired, the airway should be secured prior to lavage and emesis is contraindicated. Our Flexeril (cyclobenzaprine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction.

  • However, your physician can better decide which drug is better for your back pain.
  • Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
  • Each endpoint consisted of a score on a 5-point rating scale (from 0 or worst outcome to 4 or best outcome).
  • However, it is only for short-term relief from acute muscle pain and other skeletal conditions.
  • Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Cyclobenzaprine is a tricyclic dimethylpropanamine skeletal muscle relaxant, which is used clinically to decrease muscle spasm and hypercontractility, as well as acute musculoskeletal pain. Although the absolute mechanism of action of cyclobenzaprine remains elusive, it is known to mediate its effects centrally via inhibition of tonic somatic motor function, likely through modulation of noradrenergic and serotonergic systems. While cyclobenzaprine is effective as a muscle relaxant, greater than 30% of patients experience drowsiness and sedative-hypnotic effects, yet the mechanisms that cause this adverse effect are also undescribed.

Patients who suffer from fibromyalgia may find that cyclobenzaprine both relaxes their aching muscles and helps improve their sleep (8). Cyclobenzaprine (Flexeril) is structurally similar to TCAs and, as such, demonstrates significant anticholinergic side effects. It differs from the TCA amitriptyline by only one double bond.

Do not take more of it and do not take it more often than your doctor ordered. Ask your pharmacist any questions you have about refilling your prescription. RxList does not provide medical advice, diagnosis or treatment. Secondary endpoints included a physician’s evaluation of the presence and extent of palpable muscle spasm.

It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Your dose will depend on the severity of your pain and the formulation of cyclobenzaprine you’re using. Cyclobenzaprine is usually taken once daily for only 2 or 3 weeks. Avoid driving or hazardous activity until you know how this medicine will affect you.

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