Comparison of Ibuprofen, Cyclobenzaprine, or Both for Acute Cervical Strain: A Randomized Clinical Trial Full Text View
Even if it feels like the effects of cyclobenzaprine have worn off, the drug may not be completely eliminated from the body yet and could cause serious interactions with other substances. A post-marketing surveillance program was carried out in 7607 patients with acute musculoskeletal disorders, and included 297 patients treated with FLEXERIL 10 mg for 30 days or longer. The overall effectiveness of FLEXERIL was similar to that observed in the double-blind controlled studies; the overall incidence of adverse effects was less (see ADVERSE REACTIONS). There are no known interactions between ibuprofen and some of the more common muscle relaxants, including Flexeril (cyclobenzaprine), baclofen, benzodiazepines, and metaxalone, according to Drugs.com. That said, you should still connect with your doctor before taking ibuprofen with a muscle relaxant. According to Addiction Resource, taking muscle relaxants and ibuprofen together at higher doses can lead to slowed breathing, headache, nausea, tiredness, or constipation.
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The peak concentration varies, depending on what formulation you take. For example, the peak concentration for the extended-release pills is around seven hours. While the addictiveness of cyclobenzaprine is being debated, anyone exhibiting problematic patterns of substance use can benefit from addiction treatment.
It’s Often a Fruitless Combination
Don’t take this medicine for longer than three weeks without talking to your doctor. Call your doctor if your symptoms do not improve after 3 weeks, or if they get worse. UseCyclobenzaprine (Flexeril) exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Since overdosage is often deliberate, patients may attempt suicide by other means during the recovery phase. Less frequent dosing should be considered for hepatically impaired or elderly patients (see PRECAUTIONS, Impaired Hepatic Function, and Use in the Elderly).
- Animal studies indicate that cyclobenzaprine does not act at the neuromuscular junction or directly on skeletal muscle.
- If someone is trying to find out whether one can take these drugs and ibuprofen together, it is not recommended to mix both of them.
- The plasma concentration of cyclobenzaprine is increased in patients with hepatic impairment (see CLINICAL PHARMACOLOGY, Pharmacokinetics, Hepatic Impairment).
- Our team does their best for our readers to help them stay informed about vital healthcare decisions.
Sometimes, patients take ibuprofen, an NSAID medication that can also be used for pain conditions, to speed up their recovery. But the question is, can you take ibuprofen with muscle relaxers? It is important to mention that patients should avoid taking these drugs with ibuprofen as this may cause a dangerous drug interaction. In a report by medical doctors from Pennsylvania, the CNS side effects of these drugs can be increased by 45% if used with ibuprofen.
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In fact, Carisoprodol is even formulated with acetaminophen and caffeine. However, this does not necessarily mean that no muscle flexeril or cyclobenzaprine relaxers interactions could exist at all. In a report from Pennsylvania, at larger doses, this can induce seizures and fatality.
As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment. Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively. Although it’s common to take ibuprofen for common pains, it’s important to know how it might interact with other common medications you might already be taking. Ibuprofen somewhat thins your blood, so taking blood thinners with ibuprofen can cause excessive bleeding, according to GoodRx.
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Although useful for patients with pain conditions, it is important to understand that one can go for this combination as Aleve does not have any muscle relaxers interactions. Patients with low back pain or fibromyalgia may benefit from treatment with cyclobenzaprine. Higher doses of cyclobenzaprine or tizanidine would be appropriate to promote sedation in cases of more severe discomfort or perceived muscular spasm. Although there appears to be insufficient data on metaxalone and methocarbamol, these may be useful in patients who cannot tolerate the sedative properties of cyclobenzaprine or tizanidine. Of note, methocarbamol costs substantially less than metaxalone. Flexeril is a strong muscle relaxant used with rest and physical therapy to treat muscle spasms.
Talk to your doctor or pharmacist if you have any questions or concerns. Cyclobenzaprine usually begins working about one hour after it is ingested, relaxing muscles and relieving muscle spasms. If you are prescribed cyclobenzaprine, follow your healthcare provider’s directions for how to take it. The efficacy of FLEXERIL 5 mg was demonstrated in two seven-day, double-blind, controlled clinical trials enrolling 1405 patients.
If you notice other effects not listed above, contact your doctor or pharmacist. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Do not take more of it and do not take it more often than your doctor ordered. Painosoma.com is an information-providing website and does not sell any products.
Just remember to talk to your physician before you stop the current prescription and move on to a different treatment plan. Not only is the combination not very fruitful, but it can also come with some unpleasant effects. There are a couple of drawbacks that keep physicians from prescribing the two drugs together.